Succinic Acid – Succinic acid is an essential component of the Krebs or citric acid cycle and serves an electron donor in the production of fumaric acid and FADH2. Succinate helps reduce the effects of alcohol toxicity including hangover by activating the second half-cycle of tricarboxylic acids to help accelerate the decomposition of acetaldehyde and the energization of the oxidation processes in the mitochondria into CO2 and H2O through aerobic metabolism. Succinic acid has been shown to stimulate neural system recovery and bolster the immune system and helps boost awareness, concentration and reflexes. In nutraceutical form succinic acid is safe and approved by the FDA.
L-glutamine and N-acetyl cysteine – Alcohol inhibits the availability of glucose through an insulin-mediated mechanism. L-Glutamine and N-acetyl cysteine contain a sulfhydryl group effective in scavenging acetaldehyde and to help the liver manufacture glutathione, one of the body’s most important naturally occurring antioxidants and detoxifiers. N-acetyl cysteine (an acetylated form of the amino acid cysteine) helps increase the oxidation cycle of ethanol, lowering acetaldehyde levels in the blood, liver and brain. L-glutamine helps speed up the process of reducing NADH back to NAD+ via the malate-aspartate shuttle, to correct the cellular imbalance in the NADH/NAD+, widely believed to be one of the metabolic effects of ethanol intoxication. L-glutamine also appears to reduce the craving for sugar and carbohydrates.
L-alanine – L-Alanine is an amino acid that is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and the central nervous system. Alanine plays a major role in transferring nitrogen from tissue sites in the body to the liver, where it plays a significant role in maintaining the body’s blood sugar balance.
Silymarin (milk thistle seed extract) – Silymarin is a flavonoid found in the seeds of the dried milk thistle herb. Silymarin is a powerful proven blood and liver antioxidant that helps protect liver cells (and other cells in the body and brain) from toxicity. Silymarin and its components scavenge free radicals that can damage the liver. Sylimarin has been shown to promote liver cell protein synthesis and decreases the oxidation of glutathione. Early research indicates that silymarin may also have anti-cancer properties. In one study, silymarin retarded the development of alcohol-induced hepatic fibrosis (a scarring response to liver damage) in baboons. Milk Thistle Extract is standardized to 80% silymarin.
L-malic acid – L-malic acid, a fruit-derived amino acid, is a key intermediate in the major biochemical energy-producing cycle in cells known as the citric acid or Krebs cycle located in the cells’ mitochondria, where it plays an essential role in the production of energy.
Malic acid is absorbed from the gastrointestinal tract from whence it is transported via the portal circulation to the liver. The mitochondrial malic enzyme, particularly in brain cells, may play a key role in the pyruvate recycling pathway, which utilizes dicarboxylic acids and substrates, such as glutamine, to provide pyruvate to maintain the citric acid cycle activity when glucose and lactate are low. It also helps remove high levels of phosphorous and aluminum from the body.
Cheerz® Combats Alcohol Toxicity in Three Ways:
ONE: Helping to slow/reduce the conversion of ethanol into acetaldehyde.
Succinic acid is included to activate the second half-cycle of tricarboxylic acids, and accelerate the decomposition of acetaldehyde and energization of the oxidation processes in the mitochondria.
Further reduction of the amount of acetaldehyde produced is accomplished with the inclusion of silymarin, a powerful proven blood and liver antioxidant that helps protect liver cells (and other cells in the body and brain) from toxicity. Silymarin and its components scavenge free radicals that can damage the liver.
Glucose is included to compete with ethanol (alcohol) for available cytosol NAD, thereby creating a deficit of NAD required by ethanol in order to convert to acetaldehyde.
TWO: Helping to speed the conversion of acetaldehyde into acetic acid.
L-Glutamine (C5H10N2O3,) is included to accelerate the process of reducing NADH back to NAD+ via the malate-aspartate shuttle to correct the cellular imbalance in the NADH/NAD+, believed to be one of the metabolic effects of ethanol intoxication 2
THREE: Scavenging unmetabolized acetaldehyde.
L-Glutamine research has shown that antioxidants containing a form of sulfur called a sulfhydryl group are effective in scavenging acetaldehyde that has not been metabolized into acetic acid.
Glutathione is an aldehyde scavenger that is used by the body to “mop up” acetaldehyde. The Cheerz formula includes the glutiathione building-block supplement L-Glutamine to aid the liver in manufacturing it’s own glutathione.
Calcium Ascorbate is substituted for ascorbic acid because it is milder on the stomach lining.